I dont have vista, but I assume its similar to XP in that you get a task manager of some sort open when you press ctrl-alt-del ? and the GDK window loses focus ?
The problem would be that when the GDK window loses focus it stops sending messages to be updated.
I can think of a couple of way around it, the most basic is dont press ctrl-alt-del...
..
or you could disable those keys, either with GDK or through windows,
or you could use windows to capture those keypresses while your app is open and stop it from doing anything(kind of an extension of disabling the keys, you would need to understand how to program with windows vista though, and I personally have no xp at that so cant help)
If it ain't broke.... DONT FIX IT !!!