In the early days all games made were left-hand as it made it harder for a right-hand person to use.(fruit machines are left hand.)
eg
joystick on the left fire buttons on the right.
but now I think there no difference as they have trained this generation to use either hand.
however you can have fun changing things like the mouse pointer and where you put the menus, and the buttons like cancel.
left handed my self so your not the only one who find things wrong, at least we drive on the correct side of the road for left-hand person in the UK.
Dark Physics makes any hot drink go cold.