It's probably a good thing that your not a modeller Matt, neither am I, it means you make the modeller you want and can use instead of another complicated unfriendly mess like most of the modelling software out there!. Both will most likely work completely differently, so it's a case of using the software that makes the most sense to you.
I went for manual vertice data instead of memblock editing, although it uses a memblock to display the model, the memblock is generated from the manual vertice data. I like doing it that way because it gives total control over the vertices. For example, splitting a polygon into 3, with manual vertices, you simply average out all 3 vertice positions to find the centre of the poly. Once you have the centre, you add a vertice at the centre location and assign the polygons to suit. That is fairly straightforward using manual vertices - don't want to think how you'd do that with memblock editing.
Post some more details about DarkMESH please Matt, if there's anything your unsure off, just let me know. Good luck, and stick with it - once you get stuck into it, it's actually pretty cool working stuff like this.
Van-B
My cats breath smells of cat food.