It can be hard to transition between tools you're really used to or methods you're really used to. I've found the 3D tools I do like best are actually pretty similar in how they work, so I can use Carrara, Cinema 4D 6, Hexagon and Silo without adjusting much. However, if I try Blender, Maya PLE, Softimage|Mod Tool or even Lightwave (demo) I really struggle. They don't feel as intuitive and it feels like I'm learning 3D modelling all over again.
I think one of the troubles with Blender is that I don't think there's any tools out there that work in a similar way, so it might be harder to break away from. However, if you persist you ought to be able to pull it off. I did manage to stick with XSI Mod Tool for a little while at least, the only reason I didn't persist beyond that is because XSI Standard was dropped (which I wanted to buy) and I didn't like Mod Tool's licensing.
So it's possible to break away from the programs you're really used to using, it just takes a little bit of self-discipline.