Let's try again.
What version of Visual Studio are you using? I am using VS2010 Express (and therefore the VS2010 AppGameKit libraries).
I was able to change a watched variable during a break and restart and the program reacted to the changed variable's new value. I did not change the code, just the actual value. So that works fine in VS2010.
The reason to use the correct AppGameKit libraries for the version of Visual Studio you use is that there are significant differences in some of the core Visual Studio stuff and how the resulting AppGameKit libraries are built.
And the Debug libraries are specifically built (regardless of VS version) so that they interact properly when you are in Debug mode.
Cheers,
Ancient Lady
AGK Community Tester and AppGameKit Master