It depends kat' - ArtRage supports layers, but it might be a little unweildy for drawing character sprites or textures. For backdrops though, it's great. I think the ideal project for ArtRage would be an adventure game with hand painted backdrops, like a point and click game, something that needs a lot of nice backdrops without too much hassle or skill.
Maybe a turn based game would be nice. Like a map with icons for each player, then painted backdrops and characters for the battle scenes. Should be quite straightforward to make, no burdon of having to keep things fast and slick, and plenty of scope to personalise it, add in private jokes, mutual friends, whatever you can be bothered drawing really. For a project like that, well AppGameKit or DBPro is probably fine. AppGameKit has quick and easy font handling and straightforward sprite and image stuff, I'd say you'd get results really quickly in that.
I got a fever, and the only prescription, is more memes.