Yea spybot search and destroy is an good application but the applications i use are:
Quick Heal ( Rely Good )
GIANT AntiSpyware ( Good )
Ad-Aware Series ( Good )
Error Nuker 2004 ( Good )
Error Nuker 2004 is a good application to clean up some messy reg setting to speed up your computer ( it is a safe program

), GIANT AnitSpyware is a nice program to remove some nasty spyware crap and also protect you from getting em

, you can also help the theam by reporting the detected spyware on your ccomputer. Ad-Aware is almost as Giant AntiSpyware but with some extra functions and you can add some plugins etc. Quick Heal is my faverit application, if you register it you will get DAILY updates on virus etc.
Well thats all, i hope you learned somthing