Drawing sprites is one thing, animating them is something else entirely.
There's a few systems that you can employ to make life easier - personally I'd probably write a whole sprite and animation system in DBPro for making sprites, it just depends on what eats all your time and what you can do to dilute that overhead. Really, as long as you like the results, you can't go wrong - I mean 2D games are more of a statement, if people like the results then it's artwork, otherwise it's just sprites. Continuity is a major factor though, you should stick to a method that works through your whole game, miss-matched 2D is a real eyesore, try to embellish 1 strong style throughout and the overall effect is always better.
Van-B

Put those fiery biscuits away!