At the end of the day, 2D will never die - because there will always be developers like us using 2D techniques and media, sometimes in a 3D environment, but that's not the point.
Platforms like the NDS and GBA, and mobile phone and other handheld platforms push the need for 2D games, these are not ideal for 3D engines so 2D is still strong. I have a lot of ideas for NDS games that are all 2D. One major thing I need to do though is make a NDS sprite editor, for making pixel art, imagine using the stylus to draw pixel art while scrolling around a massive image in the top screen.
Personally, I'd rather look at Indigo's mad parrot than any number of rendered 3D parrots, it's amazing how you can convey personality and mood with simple pixels. Hehe, you shuld do a pixel art xmas card for the TGC card compo (geek culture), pixel santa etc, it would work very nicely IMO.
But as I said, 2D will never die as long as there's 1 coder and 1 customer left.

''Stick that in your text and scroll it!.''