I've taken breaks that took longer then a couple of nights.... but you need to stray far from your pc for it
Best is imo, switch the pc off for a week at a least, so something completely differently, after all there's more to life then making games.
But to really know if you really want something, you have to stop doing it completely for at least 26 days in a row. If you still desire doing it after these days, it's in your blood
If not, don't even bother picking it up again. I've read that in a scientific magazine once, they conducted a huge research on habits and breaking habits and how to determine if you really like what you're involved in.
I took a break from game design a few years back.... it lasted more then six months and I don't regret it. I learned so many cool other things (that turn out to be very useful in game design also). I've been really into creating games for the last year now, that I'm ready to take a huge break again and learn something new.
But I've already stated that before, just finishing up some game related projects and then I'll take a long break as well, at least from game design. I'll still be around and use FPSC for my 3D teaching enviroments, I had my complete none FPSC break during Christmas and that was over a week already.
So if you take a break, do it good and not a few nights only!