Personally, I think PC's have too many colours and too many artists using them because they can. I mean - if you look at old pixel art for 2D RPG's the quality is awesome and they tend to limit the pallete.
Try it - try making a little pallete of different colours, but only giving 4 shades of each colour to use.
Never blend when drawing sprites, pixel by pixel is the only way.
Start with a black outline and draw all your animations - colour it methodically after your finished animating. It's the only way to get consistency, it's often the case that you see a really nicely drawn first few sprites then they get gradually worse.
Van-B

Muhahahahaha.